Daratumumab: a first-in-class CD38 monoclonal antibody for the treatment of multiple myeloma.
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ABSTRACT:
SUBMITTER: Sanchez L
PROVIDER: S-EPMC4929758 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Daratumumab: a first-in-class CD38 monoclonal antibody for the treatment of multiple myeloma.
Sanchez Larysa L Wang Yucai Y Siegel David S DS Wang Michael L ML
Journal of hematology & oncology 20160630 1
Daratumumab is a human monoclonal antibody that targets CD38, a cell surface protein that is overexpressed on multiple myeloma (MM) cells. Preclinical studies have shown that daratumumab induces MM cell death through several mechanisms, including complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and apoptosis. Given the encouraging efficacy and acceptable safety profile of daratumumab demonstrated in cl ...[more]
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