A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia.
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ABSTRACT:
SUBMITTER: Simpson EH
PROVIDER: S-EPMC4929859 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
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A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia.
Simpson Eleanor H EH Kellendonk Christoph C Kandel Eric E
Neuron 20100301 5
The cognitive symptoms of schizophrenia are largely resistant to current treatment and are thus a life-long burden of the illness. Studies of cognitive symptoms have commonly focused on prefrontal cortex because of its demonstrated importance for executive function and working memory--key components of the deficit. The role of striatal-cortical circuitry and therefore the striatum itself has received much less attention. Here we review longstanding evidence that the striatum and its cortical con ...[more]
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