Ontology highlight
ABSTRACT:
SUBMITTER: Horikoshi N
PROVIDER: S-EPMC4929947 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Horikoshi Naoki N Arimura Yasuhiro Y Taguchi Hiroyuki H Kurumizaka Hitoshi H
Open biology 20160601 6
H2A.Z is incorporated into nucleosomes located around transcription start sites and functions as an epigenetic regulator for the transcription of certain genes. During transcriptional regulation, the heterotypic H2A.Z/H2A nucleosome containing one each of H2A.Z and H2A is formed. However, previous homotypic H2A.Z nucleosome structures suggested that the L1 loop region of H2A.Z would sterically clash with the corresponding region of canonical H2A in the heterotypic nucleosome. To resolve this iss ...[more]