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Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction.


ABSTRACT:

SUBMITTER: Estcourt LJ 

PROVIDER: S-EPMC4930145 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction.

Estcourt Lise J LJ   Stanworth Simon J SJ   Hopewell Sally S   Doree Carolyn C   Trivella Marialena M   Massey Edwin E  

The Cochrane database of systematic reviews 20160429


<h4>Background</h4>Despite modern antimicrobials and supportive therapy bacterial and fungal infections are still major complications in people with prolonged disease-related or treatment-related neutropenia. Transfusions of granulocytes have a long history of usage in clinical practice to support and treat severe infection in high-risk groups of patients with neutropenia or neutrophil dysfunction. However, there is considerable current variability in therapeutic granulocyte transfusion practice  ...[more]

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