Ontology highlight
ABSTRACT:
SUBMITTER: Peng HY
PROVIDER: S-EPMC4930189 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Peng Hsuan-Yu HY Cheng Yun-Ching YC Hsu Yuan-Ming YM Wu Guan-Hsun GH Kuo Ching-Chuan CC Liou Jing-Ping JP Chang Jang-Yang JY Jin Shiow-Lian Catherine SL Shiah Shine-Gwo SG
PloS one 20160701 7
Microtubule inhibitors have been shown to inhibit Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signal transduction pathway in various cancer cells. However, little is known of the mechanism by which the microtubule inhibitors inhibit STAT3 activity. In the present study, we examined the effect of a novel small-molecule microtubule inhibitor, MPT0B098, on STAT3 signaling in oral squamous cell carcinoma (OSCC). Treatment of various OSCC cells with MPT0B098 induced ...[more]