Ontology highlight
ABSTRACT:
SUBMITTER: Williams EK
PROVIDER: S-EPMC4930427 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Williams Erika K EK Chang Rui B RB Strochlic David E DE Umans Benjamin D BD Lowell Bradford B BB Liberles Stephen D SD
Cell 20160526 1
Neural inputs from internal organs are essential for normal autonomic function. The vagus nerve is a key body-brain connection that monitors the digestive, cardiovascular, and respiratory systems. Within the gastrointestinal tract, vagal sensory neurons detect gut hormones and organ distension. Here, we investigate the molecular diversity of vagal sensory neurons and their roles in sensing gastrointestinal inputs. Genetic approaches allowed targeted investigation of gut-to-brain afferents involv ...[more]