Ontology highlight
ABSTRACT:
SUBMITTER: Jongsma ML
PROVIDER: S-EPMC4930482 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Jongsma Marlieke L M ML Berlin Ilana I Wijdeven Ruud H M RH Janssen Lennert L Janssen George M C GM Garstka Malgorzata A MA Janssen Hans H Mensink Mark M van Veelen Peter A PA Spaapen Robbert M RM Neefjes Jacques J
Cell 20160601 1
Through a network of progressively maturing vesicles, the endosomal system connects the cell's interior with extracellular space. Intriguingly, this network exhibits a bilateral architecture, comprised of a relatively immobile perinuclear vesicle "cloud" and a highly dynamic peripheral contingent. How this spatiotemporal organization is achieved and what function(s) it curates is unclear. Here, we reveal the endoplasmic reticulum (ER)-located ubiquitin ligase Ring finger protein 26 (RNF26) as th ...[more]