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Individualized Tamoxifen Dose Escalation: Confirmation of Feasibility, Question of Utility.

ABSTRACT: Tamoxifen may require metabolic activation to endoxifen for efficacy in treating hormone receptor-positive breast cancer. Dose escalation in patients with low endoxifen concentrations could enhance treatment efficacy. This approach is clinically feasible, and successfully increases endoxifen concentrations; however, it is unknown whether patients benefit from individualized tamoxifen dose escalation. Clin Cancer Res; 22(13); 3121-3. ©2016 AACRSee related article by Fox et al., p. 3164.

SUBMITTER: Hertz DL 

PROVIDER: S-EPMC4930675 | biostudies-literature |

REPOSITORIES: biostudies-literature

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