Dataset Information

Is oocyte donation a risk factor for preeclampsia? A systematic review and meta-analysis.

ABSTRACT:

Purpose

The objective of this meta-analysis is to determine whether there is a higher incidence of preeclampsia (PE) in pregnancies achieved by oocyte donation (OD) compared with pregnancies achieved by in vitro fertilization with autologous oocytes (IVF).

Methods

A systematic review was performed to identify relevant studies published from January 1994 until April 2015 with at least an abstract in English using PubMed, ISI Web of Knowledge, and clinicaltrials.gov. The 11 studies included in this systematic review were retrospective and prospective cohort studies of women reporting results on the association between oocyte donation vs. in vitro fertilization (exposure) and preeclampsia (outcome).

Results

Oocyte donation is a risk factor for the development of PE compared to IVF cycles, with a weighted OR of 3.12 under a fixed effects method (FEM: no heterogeneity between the studies). The weighted OR under a random effects model was 2.9 (REM: heterogeneity between the studies). The meta-regression analysis showed that neither multiple pregnancies (estimate?=?0.08; p?=?0.19) nor patient age (estimate?=?-2.29; p?=?0.13) significantly explained the variability of the effect of oocyte donation on PE. Q statistic was 12.78 (p?=?0.237), suggesting absence of heterogeneity between the studies.

Conclusions

Pregnancies achieved by oocyte donation confer a threefold increase in the likelihood of developing PE than those achieved by in vitro fertilization with own oocytes. Physicians should be aware of this risk in order to both counsel patients and monitor pregnancies accordingly.

SUBMITTER: Blazquez A

PROVIDER: S-EPMC4930777 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Publications

Is oocyte donation a risk factor for preeclampsia? A systematic review and meta-analysis.

Blázquez Anna A García Désirée D Rodríguez Amelia A Vassena Rita R Figueras Francesc F Vernaeve Valérie V

Journal of assisted reproduction and genetics 20160323 7

<h4>Purpose</h4>The objective of this meta-analysis is to determine whether there is a higher incidence of preeclampsia (PE) in pregnancies achieved by oocyte donation (OD) compared with pregnancies achieved by in vitro fertilization with autologous oocytes (IVF).<h4>Methods</h4>A systematic review was performed to identify relevant studies published from January 1994 until April 2015 with at least an abstract in English using PubMed, ISI Web of Knowledge, and clinicaltrials.gov. The 11 studies ...[more]

PMID: 27007875

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Dataset Information

Is oocyte donation a risk factor for preeclampsia? A systematic review and meta-analysis.

Purpose

Methods

Results

Conclusions

Publications

Is oocyte donation a risk factor for preeclampsia? A systematic review and meta-analysis.

Similar Datasets

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