Ontology highlight
ABSTRACT:
SUBMITTER: Park PW
PROVIDER: S-EPMC4930912 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Park Pil Whan PW Ahn Jeong Yeal JY Yang Dongki D
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20160623 4
Inositol-1,4,5-triphosphate [IP3] receptors binding protein released with IP3 (IRBIT) was previously reported as an activator of NBCe1-B. Recent studies have characterized IRBIT homologue S-Adenosylhomocysteine hydrolase-like 2 (AHCYL2). AHCYL2 is highly homologous to IRBIT (88%) and heteromerizes with IRBIT. The two important domains in the N-terminus of AHCYL2 are a PEST domain and a coiled-coil domain which are highly comparable to those in IRBIT. Therefore, in this study, we tried to identif ...[more]