Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen TC
PROVIDER: S-EPMC4931010 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Nguyen Tri C TC Cao Xiaoyi X Yu Pengfei P Xiao Shu S Lu Jia J Biase Fernando H FH Sridhar Bharat B Huang Norman N Zhang Kang K Zhong Sheng S
Nature communications 20160624
The pervasive transcription of our genome presents a possibility of revealing new genomic functions by investigating RNA interactions. Current methods for mapping RNA-RNA interactions have to rely on an 'anchor' protein or RNA and often require molecular perturbations. Here we present the MARIO (Mapping RNA interactome in vivo) technology to massively reveal RNA-RNA interactions from unperturbed cells. We mapped tens of thousands of endogenous RNA-RNA interactions from mouse embryonic stem cells ...[more]