Ontology highlight
ABSTRACT:
SUBMITTER: Gao Y
PROVIDER: S-EPMC4931246 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Gao Yuan Y Wang Jinfeng J Zheng Yi Y Zhang Jinyang J Chen Shuai S Zhao Fangqing F
Nature communications 20160628
Although previous studies demonstrated circular RNAs (circRNAs) does not exclusively comprise mRNA exons, no study has extensively explored their internal structure. By combining an algorithm with long-read sequencing data and experimental validation, we, for the first time, comprehensively investigate internal components of circRNAs in 10 human cell lines and 62 fruit fly samples, and reveal the prevalence of alternative splicing (AS) events within circRNAs. Significantly, a large proportion of ...[more]