Ontology highlight
ABSTRACT:
SUBMITTER: Lee SH
PROVIDER: S-EPMC4931291 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Lee Seung Hee SH Du Jing J Stitham Jeremiah J Atteya Gourg G Lee Suho S Xiang Yaozu Y Wang Dandan D Jin Yu Y Leslie Kristen L KL Spollett Geralyn G Srivastava Anup A Mannam Praveen P Ostriker Allison A Martin Kathleen A KA Tang Wai Ho WH Hwa John J
EMBO molecular medicine 20160701 7
Diabetes mellitus (DM) is a growing international concern. Considerable mortality and morbidity associated with diabetes mellitus arise predominantly from thrombotic cardiovascular events. Oxidative stress-mediated mitochondrial damage contributes significantly to enhanced thrombosis in DM A basal autophagy process has recently been described as playing an important role in normal platelet activation. We now report a substantial mitophagy induction (above basal autophagy levels) in diabetic plat ...[more]