Ontology highlight
ABSTRACT: Background
Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans.Methods
We performed a nested case-control study (1195 primary liver cancer cases and 4640 matched controls) within the United Kingdom's Clinical Practice Research Datalink. Antibiotic use was obtained from prescription records. Multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated using conditional logistic regression.Results
Ever-use of prescription antibiotics was associated with a slightly increased risk of liver cancer, compared to non-use (OR=1.22, 95% CI=1.03-1.45). However, there was no clear dose-response relationship by the number of prescriptions or cumulative dose of antibiotic use, suggesting a non-causal association.Conclusions
Our results do not support a role of antibiotic use in liver cancer development.
SUBMITTER: Yang B
PROVIDER: S-EPMC4931369 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Yang Baiyu B Hagberg Katrina Wilcox KW Chen Jie J Sahasrabuddhe Vikrant V VV Graubard Barry I BI Jick Susan S McGlynn Katherine A KA
British journal of cancer 20160524 1
<h4>Background</h4>Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans.<h4>Methods</h4>We performed a nested case-control study (1195 primary liver cancer cases and 4640 matched controls) within the United Kingdom's Clinical Practice Research Datalink. Antibiotic use was obtain ...[more]