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Associations of antibiotic use with risk of primary liver cancer in the Clinical Practice Research Datalink.


ABSTRACT:

Background

Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans.

Methods

We performed a nested case-control study (1195 primary liver cancer cases and 4640 matched controls) within the United Kingdom's Clinical Practice Research Datalink. Antibiotic use was obtained from prescription records. Multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated using conditional logistic regression.

Results

Ever-use of prescription antibiotics was associated with a slightly increased risk of liver cancer, compared to non-use (OR=1.22, 95% CI=1.03-1.45). However, there was no clear dose-response relationship by the number of prescriptions or cumulative dose of antibiotic use, suggesting a non-causal association.

Conclusions

Our results do not support a role of antibiotic use in liver cancer development.

SUBMITTER: Yang B 

PROVIDER: S-EPMC4931369 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Publications

Associations of antibiotic use with risk of primary liver cancer in the Clinical Practice Research Datalink.

Yang Baiyu B   Hagberg Katrina Wilcox KW   Chen Jie J   Sahasrabuddhe Vikrant V VV   Graubard Barry I BI   Jick Susan S   McGlynn Katherine A KA  

British journal of cancer 20160524 1


<h4>Background</h4>Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans.<h4>Methods</h4>We performed a nested case-control study (1195 primary liver cancer cases and 4640 matched controls) within the United Kingdom's Clinical Practice Research Datalink. Antibiotic use was obtain  ...[more]

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