Nonequilibrium gating of CFTR on an equilibrium theme.
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ABSTRACT:
SUBMITTER: Jih KY
PROVIDER: S-EPMC4931552 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Nonequilibrium gating of CFTR on an equilibrium theme.
Jih Kang-Yang KY Hwang Tzyh-Chang TC
Physiology (Bethesda, Md.) 20121201 6
Malfunction of cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ABC protein superfamily that functions as an ATP-gated chloride channel, causes the lethal genetic disease, cystic fibrosis. This review focuses on the most recent findings on the gating mechanism of CFTR. Potential clinical relevance and implications to ABC transporter function are also discussed. ...[more]
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