Reduced frontal-subcortical white matter connectivity in association with suicidal ideation in major depressive disorder.

ABSTRACT: Major depressive disorder (MDD) and suicidal behavior have been associated with structural and functional changes in the brain. However, little is known regarding alterations of brain networks in MDD patients with suicidal ideation. We investigated whether or not MDD patients with suicidal ideation have different topological organizations of white matter networks compared with MDD patients without suicidal ideation. Participants consisted of 24 patients with MDD and suicidal ideation, 25 age- and gender-matched MDD patients without suicidal ideation and 31 healthy subjects. A network-based statistics (NBS) and a graph theoretical analysis were performed to assess differences in the inter-regional connectivity. Diffusion tensor imaging (DTI) was performed to assess topological changes accor

SUBMITTER: Myung W 

PROVIDER: S-EPMC4931608 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature