Neonatal Fc receptor promoter gene polymorphism does not predict pharmacokinetics of IVIg or the clinical course of GBS.
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ABSTRACT:
SUBMITTER: Fokkink WJ
PROVIDER: S-EPMC4931719 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
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Neonatal Fc receptor promoter gene polymorphism does not predict pharmacokinetics of IVIg or the clinical course of GBS.
Fokkink Willem-Jan R WJ Haarman Annechien E G AE Tio-Gillen Anne P AP van Rijs Wouter W Huizinga Ruth R van Doorn Pieter A PA Jacobs Bart C BC
Annals of clinical and translational neurology 20160517 7
Treatment of Guillain-Barré syndrome with a standard course of high-dose intravenous immunoglobulin (IVIg) results in a variable clinical recovery which is associated with changes in serum IgG levels after treatment. The neonatal Fc-receptor protects IgG from degradation, and a genetic polymorphism in its promoter region that influences the expression of Fc-receptor, may in part explain the variation in IgG levels and outcome. This polymorphism was determined by polymerase chain reaction in a co ...[more]
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