Epigenetic Mechanisms Governing Innate Inflammatory Responses.
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ABSTRACT:
SUBMITTER: Perkins DJ
PROVIDER: S-EPMC4931723 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Epigenetic Mechanisms Governing Innate Inflammatory Responses.
Perkins Darren J DJ Patel Mira C MC Blanco Jorge C G JC Vogel Stefanie N SN
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20160701 7
Toll-like receptors (TLRs) are major receptors of the host innate immune system that recognize conserved pathogen-associated molecular patterns (PAMPs) of invading microbes. Activation of TLR signaling culminates in the expression of multiple genes in a coordinate and kinetically defined manner. In this review, we summarize the current studies describing the chromatin landscape of TLR-responsive inflammatory genes and how changes to this chromatin landscape govern cell type-specific and temporal ...[more]
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