Ontology highlight
ABSTRACT:
SUBMITTER: Rivkin E
PROVIDER: S-EPMC4931916 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Rivkin Elena E Almeida Stephanie M SM Ceccarelli Derek F DF Juang Yu-Chi YC MacLean Teresa A TA Srikumar Tharan T Huang Hao H Dunham Wade H WH Fukumura Ryutaro R Xie Gang G Gondo Yoichi Y Raught Brian B Gingras Anne-Claude AC Sicheri Frank F Cordes Sabine P SP
Nature 20130524 7454
A complex interaction of signalling events, including the Wnt pathway, regulates sprouting of blood vessels from pre-existing vasculature during angiogenesis. Here we show that two distinct mutations in the (uro)chordate-specific gumby (also called Fam105b) gene cause an embryonic angiogenic phenotype in gumby mice. Gumby interacts with disheveled 2 (DVL2), is expressed in canonical Wnt-responsive endothelial cells and encodes an ovarian tumour domain class of deubiquitinase that specifically cl ...[more]