Ontology highlight
ABSTRACT:
SUBMITTER: Ben-David U
PROVIDER: S-EPMC4932194 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Ben-David Uri U Ha Gavin G Khadka Prasidda P Jin Xin X Wong Bang B Franke Lude L Golub Todd R TR
Nature communications 20160704
Aneuploidy and copy-number alterations (CNAs) are a hallmark of human cancer. Although genetically engineered mouse models (GEMMs) are commonly used to model human cancer, their chromosomal landscapes remain underexplored. Here we use gene expression profiles to infer CNAs in 3,108 samples from 45 mouse models, providing the first comprehensive catalogue of chromosomal aberrations in cancer GEMMs. Mining this resource, we find that most chromosomal aberrations accumulate late during breast tumor ...[more]