Chemical Variations on the p53 Reactivation Theme.
Ontology highlight
ABSTRACT:
SUBMITTER: Ribeiro CJ
PROVIDER: S-EPMC4932543 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Chemical Variations on the p53 Reactivation Theme.
Ribeiro Carlos J A CJ Rodrigues Cecília M P CM Moreira Rui R Santos Maria M M MM
Pharmaceuticals (Basel, Switzerland) 20160513 2
Among the tumor suppressor genes, p53 is one of the most studied. It is widely regarded as the "guardian of the genome", playing a major role in carcinogenesis. In fact, direct inactivation of the TP53 gene occurs in more than 50% of malignancies, and in tumors that retain wild-type p53 status, its function is usually inactivated by overexpression of negative regulators (e.g., MDM2 and MDMX). Hence, restoring p53 function in cancer cells represents a valuable anticancer approach. In this review, ...[more]
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