Prognosis of Adults With Borderline Left Ventricular Ejection Fraction.

ABSTRACT:

Objectives

This study sought to examine the association of a borderline left ventricular ejection fraction (LVEF) of 50% to 55% with cardiovascular morbidity and mortality in a community-based cohort.

Background

Guidelines stipulate a LVEF >55% as normal, but the optimal threshold, if any, remains uncertain. The prognosis of a "borderline" LVEF, 50% to 55%, is unknown.

Methods

This study evaluated Framingham Heart Study participants who underwent echocardiography between 1979 and 2008 (n = 10,270 person-observations, mean age 60 years, 57% women). Using pooled data with up to 12 years of follow-up and multivariable Cox regression, we evaluated the associations of borderline LVEF and continuous LVEF with the risk of developing a composite outcome (heart failure [HF] or

SUBMITTER: Tsao CW 

PROVIDER: S-EPMC4932891 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature