Ontology highlight
ABSTRACT:
SUBMITTER: Carlson ML
PROVIDER: S-EPMC4933262 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20160407 23
ATP-binding cassette transporters use an alternating access mechanism to move substrates across cellular membranes. This mode of transport ensures the selective passage of molecules while preserving membrane impermeability. The crystal structures of MalFGK2, inward- and outward-facing, show that the transporter is sealed against ions and small molecules. It has yet to be determined whether membrane impermeability is maintained when MalFGK2 cycles between these two conformations. Through the use ...[more]