Ontology highlight
ABSTRACT:
SUBMITTER: Beckerman R
PROVIDER: S-EPMC4934057 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Beckerman Rachel R Yoh Kathryn K Mattia-Sansobrino Melissa M Zupnick Andrew A Laptenko Oleg O Karni-Schmidt Orit O Ahn Jinwoo J Byeon In-Ja IJ Keezer Susan S Prives Carol C
Cell cycle (Georgetown, Tex.) 20160521 11
Functional in a tetrameric state, the protein product of the p53 tumor suppressor gene confers its tumor-suppressive activity by transactivating genes which promote cell-cycle arrest, senescence, or programmed cell death. How p53 distinguishes between these divergent outcomes is still a matter of considerable interest. Here we discuss the impact of 2 mutations in the tetramerization domain that confer unique properties onto p53. By changing lysines 351 and 357 to arginine, thereby blocking all p ...[more]