Ontology highlight
ABSTRACT:
SUBMITTER: Barbosa AD
PROVIDER: S-EPMC4934063 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Barbosa António Daniel AD Pereira Clara C Osório Hugo H Moradas-Ferreira Pedro P Costa Vítor V
Cell cycle (Georgetown, Tex.) 20160510 12
Sit4p is the catalytic subunit of a ceramide-activated PP2A-like phosphatase that regulates cell cycle, mitochondrial function, oxidative stress resistance and chronological lifespan in yeast. In this study, we show that hexokinase 2 (Hxk2p) is hyperphosphorylated in sit4Δ mutants grown in glucose medium by a Snf1p-independent mechanism and Hxk2p-S15A mutation suppresses phenotypes associated with SIT4 deletion, namely growth arrest at G1 phase, derepression of mitochondrial respiration, H2O2 re ...[more]