Ontology highlight
ABSTRACT:
SUBMITTER: Anderson JL
PROVIDER: S-EPMC4934909 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Anderson Jenny L JL Mota Talia M TM Evans Vanessa A VA Kumar Nitasha N Rezaei Simin D SD Cheong Karey K Solomon Ajantha A Wightman Fiona F Cameron Paul U PU Lewin Sharon R SR
PloS one 20160706 7
Developing robust in vitro models of HIV latency is needed to better understand how latency is established, maintained and reversed. In this study, we examined the effects of donor variability, HIV titre and co-receptor usage on establishing HIV latency in vitro using two models of HIV latency. Using the CCL19 model of HIV latency, we found that in up to 50% of donors, CCL19 enhanced latent infection of resting CD4+ T-cells by CXCR4-tropic HIV in the presence of low dose IL-2. Increasing the inf ...[more]