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T-cell therapies for HIV: Preclinical successes and current clinical strategies.

ABSTRACT: Although antiretroviral therapy (ART) has been successful in controlling HIV infection, it does not provide a permanent cure, requires lifelong treatment, and HIV-positive individuals are left with social concerns such as stigma. The recent application of T cells to treat cancer and viral reactivations post-transplant offers a potential strategy to control HIV infection. It is known that naturally occurring HIV-specific T cells can inhibit HIV initially, but this response is not sustained in the majority of people living with HIV. Genetically modifying T cells to target HIV, resist infection, and persist in the immunosuppressive environment found in chronically infected HIV-positive individuals might provide a therapeutic solution for HIV. This review focuses on successful preclinical studies and current clinical strategies using T-cell therapy to control HIV infection and mediate a functional cure solution.

SUBMITTER: Patel S

PROVIDER: S-EPMC4935558 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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T-cell therapies for HIV: Preclinical successes and current clinical strategies.

Patel Shabnum S Jones R Brad RB Nixon Douglas F DF Bollard Catherine M CM

Cytotherapy 20160602 8

Although antiretroviral therapy (ART) has been successful in controlling HIV infection, it does not provide a permanent cure, requires lifelong treatment, and HIV-positive individuals are left with social concerns such as stigma. The recent application of T cells to treat cancer and viral reactivations post-transplant offers a potential strategy to control HIV infection. It is known that naturally occurring HIV-specific T cells can inhibit HIV initially, but this response is not sustained in the ...[more]

PMID: 27265874

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