Ontology highlight
ABSTRACT:
SUBMITTER: Pember SO
PROVIDER: S-EPMC4936272 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Pember Stephen O SO Mejia Galo L GL Price Theodore J TJ Pasteris Robert J RJ
Bioorganic & medicinal chemistry letters 20160222 12
Fatty acid amide hydrolase (FAAH) is a membrane anchored serine hydrolase that has a principle role in the metabolism of the endogenous cannabinoid anandamide. Docking studies using representative FAAH crystal structures revealed that compounds containing a novel piperidinyl thiazole isoxazoline core fit within the ligand binding domains. New potential FAAH inhibitors were designed and synthesized incorporating urea, carbamate, alkyldione and thiourea reactive centers as potential pharmacophores ...[more]