Comparison of pharmacokinetics of tramadol between young and middle-aged dogs.
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ABSTRACT:
SUBMITTER: Itami T
PROVIDER: S-EPMC4937138 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Comparison of pharmacokinetics of tramadol between young and middle-aged dogs.
Itami Takaharu T Saito Yasuo Y Ishizuka Tomohito T Tamura Jun J Umar Mohammed A MA Inoue Hiroki H Miyoshi Kenjiro K Yamashita Kazuto K
The Journal of veterinary medical science 20160211 6
This study aimed to compare the pharmacokinetics of tramadol between young and middle-aged dogs. Tramadol (4 mg/kg) was administered intravenously (IV) to young and middle-aged dogs (2 and 8-10 years, respectively). Plasma concentrations of tramadol were measured using high-performance liquid chromatography (HPLC), and its pharmacokinetics best fit a two-compartment model. The volume of distribution (Vd), elimination half-life (t1/2,β) and total body clearance (CLtot) of the young group were 4.7 ...[more]
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