Salmonella Degrades the Host Glycocalyx Leading to Altered Infection and Glycan Remodeling.
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ABSTRACT:
SUBMITTER: Arabyan N
PROVIDER: S-EPMC4937416 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Salmonella Degrades the Host Glycocalyx Leading to Altered Infection and Glycan Remodeling.
Arabyan Narine N Park Dayoung D Foutouhi Soraya S Weis Allison M AM Huang Bihua C BC Williams Cynthia C CC Desai Prerak P Shah Jigna J Jeannotte Richard R Kong Nguyet N Lebrilla Carlito B CB Weimer Bart C BC
Scientific reports 20160708
Complex glycans cover the gut epithelial surface to protect the cell from the environment. Invasive pathogens must breach the glycan layer before initiating infection. While glycan degradation is crucial for infection, this process is inadequately understood. Salmonella contains 47 glycosyl hydrolases (GHs) that may degrade the glycan. We hypothesized that keystone genes from the entire GH complement of Salmonella are required to degrade glycans to change infection. This study determined that GH ...[more]
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