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Impact of host responses on control of hepatitis C virus infection in Chinese blood donors.

ABSTRACT: A study was undertaken to explore the molecular mechanisms underlying control of HCV infection in blood donors in China. Factors including clinical information, anti-HCV reactivity (S/CO), IFN-? and IFN-?, viral loads and genotypes were correlated with 160 index plasma samples at three statuses of 45 recovered, 76 chronic or 39 false positive anti-HCV reactive blood donors. The spontaneous recovery rate was 37.2%. Viral loads of 76 HCV plasmas ranged between 59.8 IU/ml and 2.43 × 10(6)IU/ml (median 3.67 × 10(4)IU/ml). Genotypes 1, 2, 3 and 6 of 63 HCV strains were identified phylogenetically. Recovered donors were significantly younger (p=0.002) and had lower level IFN-? (p=0.001) than chronically HCV infected donors. Circulating levels of IFN-? and IFN-? were higher in those with low viral load and were low in middle or high viral load samples. The ratio of IFN-? to IFN-? (IFN-?/?) was significantly positively correlated with viral load (p=0.037), and viral load was inversely correlated with IFN-? in chronic HCV infection regardless of genotype. The study revealed clearly different relationships between IFN-? and IFN-? in relation to viral load in HCV. A novel measure of IFN-?/? ratio could be a new approach to evaluate long term outcome of HCV infection.

SUBMITTER: Li T

PROVIDER: S-EPMC4937991 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Impact of host responses on control of hepatitis C virus infection in Chinese blood donors.

Li Tingting T Chen Zixuan Z Zeng Jinfeng J Zhang Jingang J Wang Wenjing W Zhang Ling L Zheng Xin X Shuai Lifang L Klenerman Paul P Allain Jean-Pierre JP Li Chengyao C

Biochemical and biophysical research communications 20111029 3

A study was undertaken to explore the molecular mechanisms underlying control of HCV infection in blood donors in China. Factors including clinical information, anti-HCV reactivity (S/CO), IFN-α and IFN-γ, viral loads and genotypes were correlated with 160 index plasma samples at three statuses of 45 recovered, 76 chronic or 39 false positive anti-HCV reactive blood donors. The spontaneous recovery rate was 37.2%. Viral loads of 76 HCV plasmas ranged between 59.8 IU/ml and 2.43 × 10(6)IU/ml (med ...[more]

PMID: 22062549

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Project description:BackgroundHepatitis G virus (HGV) infection transmitted from blood donors is a concern in China, as many articles about HGV infection in Chinese blood donors from different provinces have been published. This study aimed to evaluate the overall prevalence of HGV infection in Chinese blood donors and analyse the potential risk of HGV infection through blood transfusion in China.MethodsWe performed a literature search in PubMed, EMBASE, Web of Science, the Chinese BioMedical Literature Database (CBM) and the China National Knowledge Infrastructure (CNKI) up to October 2018 regarding the prevalence of HGV in Chinese blood donors. Eligibility assessment and data extraction were conducted independently by 2 researchers, and meta-analysis was performed to synthesize the data. Heterogeneity was evaluated using Cochran's Q test and quantified using the I2 statistic. Subgroup analyses were performed to identify the possible sources of heterogeneity. Publication bias was assessed using both funnel plot and Egger's tests.ResultsA total of 102 studies with 67,348 blood donors published from 1996 to 2016 and covering 26 provinces or municipalities were included for further analyses. The pooled prevalence of HGV was 3.91% (95%CI: 3.18-4.71%) by enzyme immune assay/enzyme linked immunosorbent assay (EIA/ELISA) and 3.25% (95%CI: 2.35-4.26%) by polymerase chain reaction (PCR). The prevalence of HGV may be significantly affected by region, province or municipality and potentially by the paid/voluntary status of the blood donors. No significant difference was found between plasma and full blood donation.ConclusionsThe prevalence of HGV in blood donors from China was similar to that in blood donors from many other countries and higher than that of some other hepatitis viruses, such as hepatitis B virus. The risk of transfusion-transmitted HGV still exists after routine blood donor screening, especially in those patients coinfected with other hepatitis viruses and/or HIV. On the basis of our study, we may suggest adding HGV screening for blood transfusions in mainland China in the future.

Dataset Information

Impact of host responses on control of hepatitis C virus infection in Chinese blood donors.

Publications

Impact of host responses on control of hepatitis C virus infection in Chinese blood donors.

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