Ontology highlight
ABSTRACT:
SUBMITTER: Mosca B
PROVIDER: S-EPMC4938177 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Mosca Barbara B Eckhardt Jan J Bergamelli Leda L Treves Susan S Bongianino Rossana R De Negri Marco M Priori Silvia G SG Protasi Feliciano F Zorzato Francesco F
The Journal of biological chemistry 20160504 28
We exploited a variety of mouse models to assess the roles of JP45-CASQ1 (CASQ, calsequestrin) and JP45-CASQ2 on calcium entry in slow twitch muscles. In flexor digitorum brevis (FDB) fibers isolated from JP45-CASQ1-CASQ2 triple KO mice, calcium transients induced by tetanic stimulation rely on calcium entry via La(3+)- and nifedipine-sensitive calcium channels. The comparison of excitation-coupled calcium entry (ECCE) between FDB fibers from WT, JP45KO, CASQ1KO, CASQ2KO, JP45-CASQ1 double KO, J ...[more]