Ontology highlight
ABSTRACT:
SUBMITTER: Forstneric V
PROVIDER: S-EPMC4938411 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Forstnerič Vida V Ivičak-Kocjan Karolina K Ljubetič Ajasja A Jerala Roman R Benčina Mojca M
PloS one 20160708 7
Toll-like receptor 5 (TLR5) is a receptor of the innate immune system that recognizes flagellin from certain bacterial species and triggers an inflammatory response. The Salmonella dublin flagellin in complex with zebrafish TLR5 has been crystallized previously. In the present study, we extrapolate the structure of this complex using structure-guided mutagenesis to determine the recognition modes of human and mouse TLR5 receptors and demonstrate species-specific differences in flagellin recognit ...[more]