Ontology highlight
ABSTRACT:
SUBMITTER: Liokatis S
PROVIDER: S-EPMC4939407 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20160524 29
Post-translational modifications (PTMs) of histones regulate chromatin structure and function. Because nucleosomes contain two copies each of the four core histones, the establishment of different PTMs on individual "sister" histones in the same nucleosomal context, that is, asymmetric histone PTMs, are difficult to analyze. Here, we generated differentially isotope-labeled nucleosomes to study asymmetric histone modification crosstalk by time-resolved NMR spectroscopy. Specifically, we present ...[more]