Ontology highlight
ABSTRACT:
SUBMITTER: Saredi G
PROVIDER: S-EPMC4939875 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Saredi Giulia G Huang Hongda H Hammond Colin M CM Alabert Constance C Bekker-Jensen Simon S Forne Ignasi I Reverón-Gómez Nazaret N Foster Benjamin M BM Mlejnkova Lucie L Bartke Till T Cejka Petr P Mailand Niels N Imhof Axel A Patel Dinshaw J DJ Groth Anja A
Nature 20160622 7609
After DNA replication, chromosomal processes including DNA repair and transcription take place in the context of sister chromatids. While cell cycle regulation can guide these processes globally, mechanisms to distinguish pre- and post-replicative states locally remain unknown. Here we reveal that new histones incorporated during DNA replication provide a signature of post-replicative chromatin, read by the human TONSL–MMS22L homologous recombination complex. We identify the TONSL ankyrin repeat ...[more]