Relationship between Fetuin A, Vascular Calcification and Fracture Risk in Dialysis Patients.

ABSTRACT:

Background

Fractures are a common morbidity that lead to worse outcomes in dialysis patients. Fetuin A inhibits vascular calcification (VC), potentially promotes bone mineralization and its level positively correlates with bone mineral density in the general population. On the other hand, the presence of VC is associated with low bone volume in dialysis patients. Whether the fetuin A level and VC can predict the occurrence of fractures in dialysis patients remains unknown.

Methods

We performed this prospective, observational cohort study including 685 dialysis patients (629 hemodialysis and 56 peritoneal dialysis) from a single center in Taiwan for a median follow-up period of 3.4 years. The baseline fetuin A level and status of presence of aortic arch calcification (VC) and

SUBMITTER: Chen HY 

PROVIDER: S-EPMC4939952 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature