Altered Hepatic Transport by Fetal Arsenite Exposure in Diet-Induced Fatty Liver Disease.
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ABSTRACT:
SUBMITTER: Ditzel EJ
PROVIDER: S-EPMC4940226 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
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Altered Hepatic Transport by Fetal Arsenite Exposure in Diet-Induced Fatty Liver Disease.
Ditzel Eric J EJ Li Hui H Foy Caroline E CE Perrera Alec B AB Parker Patricia P Renquist Benjamin J BJ Cherrington Nathan J NJ Camenisch Todd D TD
Journal of biochemical and molecular toxicology 20160218 7
Non-alcoholic fatty liver disease can result in changes to drug metabolism and disposition potentiating adverse drug reactions. Furthermore, arsenite exposure during development compounds the severity of diet-induced fatty liver disease. This study examines the effects of arsenite potentiated diet-induced fatty liver disease on hepatic transport in male mice. Changes were detected for Mrp2/3/4 hepatic transporter gene expression as well as for Oatp1a4/2b1/1b2. Plasma concentrations of Mrp and Oa ...[more]
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