Ontology highlight
ABSTRACT:
SUBMITTER: Zhuang Q
PROVIDER: S-EPMC4940266 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Zhuang Qinggeng Q Young Amneh A Callam Christopher S CS McElroy Craig A CA Ekici Özlem Dogan ÖD Yoder Ryan J RJ Hadad Christopher M CM
Annals of the New York Academy of Sciences 20160621 1
Aging is a dealkylation reaction of organophosphorus (OP)-inhibited acetylcholinesterase (AChE). Despite many studies to date, aged AChE cannot be reactivated directly by traditional pyridinium oximes. This review summarizes strategies that are potentially valuable in the treatment against aging in OP poisoning. Among them, retardation of aging seeks to lower the rate of aging through the use of AChE effectors. These drugs should be administered before AChE is completely aged. For postaging trea ...[more]