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Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer.


ABSTRACT: The annexins (ANXs) have diverse roles in tumor development and progression, however, their clinical significance in cervical cancer has not been elucidated. The present study was to investigate the clinical significance of annexin A2 (ANXA2) and annexin A4 (ANXA4) expression in cervical cancer.ANXA2 and ANXA4 immunohistochemical staining were performed on a cervical cancer tissue microarray consisting of 46 normal cervical epithelium samples and 336 cervical cancer cases and compared the data with clinicopathological variables, including the survival of cervical cancer patients.ANXA2 expression was lower in cancer tissue (p?=?0.002), whereas ANXA4 staining increased significantly in cancer tissues (p?

SUBMITTER: Choi CH 

PROVIDER: S-EPMC4940752 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer.

Choi Chel Hun CH   Chung Joon-Yong JY   Chung Eun Joo EJ   Sears John D JD   Lee Jeong-Won JW   Bae Duk-Soo DS   Hewitt Stephen M SM  

BMC cancer 20160711


<h4>Background</h4>The annexins (ANXs) have diverse roles in tumor development and progression, however, their clinical significance in cervical cancer has not been elucidated. The present study was to investigate the clinical significance of annexin A2 (ANXA2) and annexin A4 (ANXA4) expression in cervical cancer.<h4>Methods</h4>ANXA2 and ANXA4 immunohistochemical staining were performed on a cervical cancer tissue microarray consisting of 46 normal cervical epithelium samples and 336 cervical c  ...[more]

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