Ontology highlight
ABSTRACT:
SUBMITTER: Yao M
PROVIDER: S-EPMC4941051 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Yao Mingxi M Goult Benjamin T BT Klapholz Benjamin B Hu Xian X Toseland Christopher P CP Guo Yingjian Y Cong Peiwen P Sheetz Michael P MP Yan Jie J
Nature communications 20160707
Talin, a force-bearing cytoplasmic adapter essential for integrin-mediated cell adhesion, links the actin cytoskeleton to integrin-based cell-extracellular matrix adhesions at the plasma membrane. Its C-terminal rod domain, which contains 13 helical bundles, plays important roles in mechanosensing during cell adhesion and spreading. However, how the structural stability and transition kinetics of the 13 helical bundles of talin are utilized in the diverse talin-dependent mechanosensing processes ...[more]