Ontology highlight
ABSTRACT:
SUBMITTER: Weissbein U
PROVIDER: S-EPMC4941052 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nature communications 20160707
Genomic instability has profound effects on cellular phenotypes. Studies have shown that pluripotent cells with abnormal karyotypes may grow faster, differentiate less and become more resistance to apoptosis. Previously, we showed that microarray gene expression profiles can be utilized for the analysis of chromosomal aberrations by comparing gene expression levels between normal and aneuploid samples. Here we adopted this method for RNA-Seq data and present eSNP-Karyotyping for the detection of ...[more]