Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC4941255 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Zhang Ziqiang Z Zhou Nanjiang N Huang Jianguo J Ho Tsui-Ting TT Zhu Zhuxian Z Qiu Zhongmin Z Zhou Xinchun X Bai Chunxue C Wu Fangting F Xu Min M Mo Yin-Yuan YY
Oncotarget 20160301 13
The androgen receptor (AR) is required for prostate development and is also a major driver of prostate cancer pathogenesis. Thus androgen deprivation therapy (ADT) is the mainstay of treatment for advanced prostate cancer. However, castration resistance due to expression of constitutively active AR splice variants is a significant challenge to prostate cancer therapy; little is known why effectiveness of ADT can only last for a relatively short time. In the present study, we show that PCGEM1 int ...[more]