Protective effect of ?-lipoic acid against radiation-induced fibrosis in mice.
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ABSTRACT:
SUBMITTER: Ryu SH
PROVIDER: S-EPMC4941260 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Protective effect of α-lipoic acid against radiation-induced fibrosis in mice.
Ryu Seung-Hee SH Park Eun-Young EY Kwak Sungmin S Heo Seung-Ho SH Ryu Je-Won JW Park Jin-Hong JH Choi Kyung-Chul KC Lee Sang-Wook SW
Oncotarget 20160301 13
Radiation-induced fibrosis (RIF) is one of the most common late complications of radiation therapy. We found that α-lipoic acid (α-LA) effectively prevents RIF. In RIF a mouse model, leg contracture assay was used to test the in vivo efficacy of α-LA. α-LA suppressed the expression of pro-fibrotic genes after irradiation, both in vivo and in vitro, and inhibited the up-regulation of TGF-β1-mediated p300/CBP activity. Thus, α-LA prevents radiation-induced fibrosis (RIF) by inhibiting the transcri ...[more]
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