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Protective effect of ?-lipoic acid against radiation-induced fibrosis in mice.

ABSTRACT: Radiation-induced fibrosis (RIF) is one of the most common late complications of radiation therapy. We found that ?-lipoic acid (?-LA) effectively prevents RIF. In RIF a mouse model, leg contracture assay was used to test the in vivo efficacy of ?-LA. ?-LA suppressed the expression of pro-fibrotic genes after irradiation, both in vivo and in vitro, and inhibited the up-regulation of TGF-?1-mediated p300/CBP activity. Thus, ?-LA prevents radiation-induced fibrosis (RIF) by inhibiting the transcriptional activity of NF-?B through inhibition of histone acetyltransferase activity. ?-LA is a new therapeutic methods that can be used in the prevention-treatment of RIF.

SUBMITTER: Ryu SH 

PROVIDER: S-EPMC4941260 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Protective effect of α-lipoic acid against radiation-induced fibrosis in mice.

Ryu Seung-Hee SH   Park Eun-Young EY   Kwak Sungmin S   Heo Seung-Ho SH   Ryu Je-Won JW   Park Jin-Hong JH   Choi Kyung-Chul KC   Lee Sang-Wook SW  

Oncotarget 20160301 13

Radiation-induced fibrosis (RIF) is one of the most common late complications of radiation therapy. We found that α-lipoic acid (α-LA) effectively prevents RIF. In RIF a mouse model, leg contracture assay was used to test the in vivo efficacy of α-LA. α-LA suppressed the expression of pro-fibrotic genes after irradiation, both in vivo and in vitro, and inhibited the up-regulation of TGF-β1-mediated p300/CBP activity. Thus, α-LA prevents radiation-induced fibrosis (RIF) by inhibiting the transcri  ...[more]

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