Ontology highlight
ABSTRACT:
SUBMITTER: Tang L
PROVIDER: S-EPMC4941273 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Tang Li L Yi Xue-Mei XM Chen Jia J Chen Fu-Juan FJ Lou Wei W Gao Yun-Lu YL Zhou Jing J Su Li-Na LN Xu Xin X Lu Jia-Qing JQ Ma Jun J Yu Ning N Ding Yang-Feng YF
Oncotarget 20160301 13
Melanoma is the most aggressive type of skin cancer, exhibiting extensive local invasion and early distant metastasis. Aberrant expression of ubiquitin-protein ligase E3C (UBE3C) plays a key role in tumor development and progression. In the present study, we analyzed UBE3C expression in samples of cancerous and normal skin tissue. Levels of UBE3C expression were much higher in primary and metastatic melanoma tissues than in normal skin, cutaneous squamous cell carcinoma or basal cell carcinoma. ...[more]