Ontology highlight
ABSTRACT:
SUBMITTER: Goracci L
PROVIDER: S-EPMC4941420 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Goracci Laura L Deschamps Nathalie N Randazzo Giuseppe Marco GM Petit Charlotte C Dos Santos Passos Carolina C Carrupt Pierre-Alain PA Simões-Pires Claudia C Nurisso Alessandra A
Scientific reports 20160712
The human histone deacetylase isoform 6 (HDAC6) has been demonstrated to play a major role in cell motility and aggresome formation, being interesting for the treatment of multiple tumour types and neurodegenerative conditions. Currently, most HDAC inhibitors in preclinical or clinical evaluations are non-selective inhibitors, characterised by a hydroxamate zinc-binding group (ZBG) showing off-target effects and mutagenicity. The identification of selective HDAC6 inhibitors with novel chemical p ...[more]