Ontology highlight
ABSTRACT:
SUBMITTER: Heckerman D
PROVIDER: S-EPMC4941438 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Heckerman David D Gurdasani Deepti D Kadie Carl C Pomilla Cristina C Carstensen Tommy T Martin Hilary H Ekoru Kenneth K Nsubuga Rebecca N RN Ssenyomo Gerald G Kamali Anatoli A Kaleebu Pontiano P Widmer Christian C Sandhu Manjinder S MS
Proceedings of the National Academy of Sciences of the United States of America 20160701 27
The linear mixed model (LMM) is now routinely used to estimate heritability. Unfortunately, as we demonstrate, LMM estimates of heritability can be inflated when using a standard model. To help reduce this inflation, we used a more general LMM with two random effects-one based on genomic variants and one based on easily measured spatial location as a proxy for environmental effects. We investigated this approach with simulated data and with data from a Uganda cohort of 4,778 individuals for 34 p ...[more]