Ontology highlight
ABSTRACT:
SUBMITTER: Wheeler GM
PROVIDER: S-EPMC4942070 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Wheeler Graham M GM Sweeting Michael J MJ Mander Adrian P AP
PloS one 20160712 7
In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download ...[more]