Ontology highlight
ABSTRACT:
SUBMITTER: Yen CF
PROVIDER: S-EPMC4942324 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Yen Chi-Fu CF Harischandra Dilshan S DS Kanthasamy Anumantha A Sivasankar Sanjeevi S
Science advances 20160701 7
Prion protein (PrP) misfolding and oligomerization are key pathogenic events in prion disease. Copper exposure has been linked to prion pathogenesis; however, its mechanistic basis is unknown. We resolve, with single-molecule precision, the molecular mechanism of Cu(2+)-induced misfolding of PrP under physiological conditions. We also demonstrate that misfolded PrPs serve as seeds for templated formation of aggregates, which mediate inflammation and degeneration of neuronal tissue. Using a singl ...[more]