Ontology highlight
ABSTRACT:
SUBMITTER: Chu J
PROVIDER: S-EPMC4942401 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Chu Jun J Oh Younghee Y Sens Alex A Ataie Niloufar N Dana Hod H Macklin John J JJ Laviv Tal T Welf Erik S ES Dean Kevin M KM Zhang Feijie F Kim Benjamin B BB Tang Clement Tran CT Hu Michelle M Baird Michelle A MA Davidson Michael W MW Kay Mark A MA Fiolka Reto R Yasuda Ryohei R Kim Douglas S DS Ng Ho-Leung HL Lin Michael Z MZ
Nature biotechnology 20160530 7
Orange-red fluorescent proteins (FPs) are widely used in biomedical research for multiplexed epifluorescence microscopy with GFP-based probes, but their different excitation requirements make multiplexing with new advanced microscopy methods difficult. Separately, orange-red FPs are useful for deep-tissue imaging in mammals owing to the relative tissue transmissibility of orange-red light, but their dependence on illumination limits their sensitivity as reporters in deep tissues. Here we describ ...[more]