APOE2 Is Associated with Spatial Navigational Strategies and Increased Gray Matter in the Hippocampus.
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ABSTRACT:
SUBMITTER: Konishi K
PROVIDER: S-EPMC4942687 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
APOE2 Is Associated with Spatial Navigational Strategies and Increased Gray Matter in the Hippocampus.
Konishi Kyoko K Bhat Venkat V Banner Harrison H Poirier Judes J Joober Ridha R Bohbot Véronique D VD
Frontiers in human neuroscience 20160713
The Apolipoprotein E (APOE) gene has a strong association with Alzheimer's disease (AD). The ε4 allele is a well-documented genetic risk factor of AD. In contrast, the ε2 allele of the APOE gene is known to be protective against AD. Much of the focus on the APOE gene has been on the ε4 allele in both young and older adults and few studies have looked into the cognitive and brain structure correlates of the ε2 allele, especially in young adults. In the current study, we investigated the relations ...[more]
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